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Hormonal regulation is an essential mechanism for the body and is responsible for maintaining the body's homeostasis and regulating physiological processes, including growth, metabolism, reproduction, and response to stress. Hormones are chemical messengers released from endocrine glands and delivered via the bloodstream to target tissues. Feedback loops modulate this intricate system —negative feedback predominates—which maintains equilibrium in hormone output (Huether & McCance, 2019). However, dysregulation of hormones can occur due to multiple factors and has severe health implications. Hormonal dysregulation is primarily caused by continued dysfunction of the endocrine gland. Glandular malfunction is seen in disorders like hypothyroidism and hyperthyroidism. In hypothyroidism, the body produces too few thyroid hormones, resulting in fatigue, weight gain, and depression. Hyperthyroidism, on the other hand, is characterized by excessive hormone production, leading to weight loss, anxiety, and tachycardia. These two conditions demonstrate how an imbalanced state can generally interfere with metabolism and health (Huether & McCance, 2019). External factors, such as diet, environmental toxins, and stress, also affect it. Chronic stress, for example, causes hypothalamic-pituitary-adrenal (HPA) axis hyperactivation and elevated cortisol levels. Prolonged elevation of cortisol has been shown to play a role in the development of obesity, hypertension, and decreased immune function (Turner et al., 2020). Likewise, exposure to endocrine-disrupting chemicals (EDCs) (such as bisphenol A (BPA) and phthalates) may also bind to hormone receptors and disturb hormone signaling pathways. EDCs have been associated with reproductive disorders, metabolic diseases, and developmental malformations (Gore et al., 2021) Autoimmune disease is another common cause of the hormonal disruption. Type 1 diabetes mellitus and Addison's disease are classic examples of immune-mediated destruction of an endocrine gland. 2 Type 1 diabetes is characterized by antibody-mediated destruction of pancreatic beta cells that render the patient unable to release insulin, resulting in hyperglycemia and its attendant complications. Aside from this, Addison's disease, which is caused by adrenal gland hypofunction, brings symptoms including fatigue, hypotension, and hyperpigmentation (Huether & McCance, 2019). Thus, understanding hypothalamic mechanisms that govern hormonal rhythms and their dysregulation is essential to designing prevention and treatment approaches. Identifying and treating endocrine disease, improving lifestyle, and reducing exposure to endocrine-disrupting chemicals can early correct hormonal dysregulation. Lastly, new horizons appear with the advent of targeted therapies and bio-identical hormones that could help remove the burden of hormonal changes. References Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., … Zoeller, R. T. (2021). EDC-2: The Endocrine Society's second scientific statement on endocrine-disrupting chemicals. Endocrine Reviews, 42(2), 91–150. https://doi.org/10.1210/endrev/bnaa012 Huether, S. E., & McCance, K. L. (2019). Understanding pathophysiology (7th ed.). Elsevier Health Sciences. Turner, A. I., Smyth, N., Hall, S. J., Torres, S. J., & Hussein, M. (2020). Psychological stress and cortisol during pregnancy: An updated systematic review and meta-analysis. Psychoneuroendocrinology, 122, 104865. https://doi.org/10.1016/j.psyneuen.2020.104865